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Strategies for producing natural and non-natural chemicals by microorganisms

Friday, May 18, 2012

In our everyday life, we use gasoline, diesel, plastics, rubbers, and numerous chemicals that are derived from fossil oil through petrochemical refinery processes. Fossil resources are limited and not sustainable. Our world is facing problems associated with climate change and other environmental problems resulted from lavish consumption of fossil fuels. One solution to address these problems is to use renewable, non-food biomass for the production of chemicals, fuels, and materials through biorefineries.

In their paper published online in Nature Chemical Biology on May 17th, Professor Sang Yup Lee and his colleagues at the Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), newly present general strategies for systems metabolic engineering to develop microorganisms for the production of natural and non-natural chemicals from renewable biomass.

Microorganisms are used as biocatalysts to convert biomass into the products of interest. When microorganisms are isolated from nature, however, their efficiency of producing desired chemicals and materials is rather low. Metabolic engineering is performed to improve cellular characteristics to desired levels.

Over the last decade, great advances have been made in systems biology that allows system-wide characterization of cellular networks, both qualitatively and quantitatively, followed by whole-cell level engineering based on these findings. Furthermore, rapid advances in synthetic biology allow design and synthesis of fine controlled metabolic and gene regulatory circuits. The strategies and methods of systems biology and synthetic biology are rapidly integrated with metabolic engineering, thus resulting in "systems metabolic engineering."

According to the paper, the researchers classified the chemicals to be produced into four categories based on whether they have been identified thus far to exist in nature (natural vs. non-natural) and they can be produced by inherent pathways of microorganisms (inherent, noninherent, or created): natural-inherent, natural-noninherent, non-natural-noninherent, and non-natural-created ones.

General strategies for systems metabolic engineering of microorganisms for the production of these chemicals using various tools and methods based on omics, genome-scale metabolic modeling and simulation, evolutionary engineering, and synthetic biology are suggested with relevant examples. For the production of non-natural chemicals, strategies for the construction of synthetic metabolic pathways are also suggested. Having collected diverse tools and methods for systems metabolic engineering, the authors also suggest how to use them and their possible limitations.

Professor Sang Yup Lee said, "It is expected that increasing number of chemicals and materials will be produced through biorefineries. We are now equipped with new strategies for developing microbial strains that can produce our desired products at very high efficiencies, thus allowing cost competitiveness to those produced by petrochemical refineries."

###

The Korea Advanced Institute of Science and Technology (KAIST): http://www.kaist.edu/english/

Thanks to The Korea Advanced Institute of Science and Technology (KAIST) for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Brady's Blog: Advice from the Community for the Campus with ...

Brady?s Blog with Weisbrod and Associates!

Follow Brady Lowe, Community Relations and Communications with Globe University-La Crosse, as he collects advice from Globe community partners to share with students!

Brady Lowe of Globe University with Laura Stiehl of Weisbrod and Associates.

Laura Stiehl, Office Manager of Weisbrod and Associates Accounting Firm, has been a guest speaker in Brady?s business classes and serves with Brady as a La Crosse Chamber of Commerce Ambassador.

Q: What advice would you give accounting and business students so they can learn more about future careers in their field?

A: Ask questions.? Seek out people in your chosen field and express an interest in knowing what they do.? Talk with your teachers about internship opportunities.? Participate in ?job expos? and, again, ask questions.? Research careers on the internet, as well, there is a lot of information out there.?Look for it!

Terrific advice Laura! Students, if you want to learn more about future career opportunities, visit with Career Services! Sarah?Thompson, Carolyn?Moe, and Crystal?Layland are glad to help!

If you?re a community partner that would like to share advice with Globe students, or know someone who would, please contact Brady Lowe. He?d be happy to hear from you!

Brady Lowe manages Communications and Community Relations at Globe University-La Crosse. He teaches business classes, coordinates volunteer activities for students and staff, and represents Globe University at various community events. If you have a story idea for Brady, please let him know! He'd be happy to hear from you: blowe@globeuniversity.edu

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Kiplinger's Personal Finance - July 2012 ? Download magazine free ...

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Written to help you do a better job of managing your personal and family financial affairs and to help you get more for your money. You get ideas on saving, investing, cutting taxes, making major purchases, advancing your career, buying a home, paying for education, health care and travel, plus much, much more. Special issues cover the latest information about car buying (December) and Mutual Funds (March and September).

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Magazine Kiplinger's Personal Finance - July 2012 free download, journal Kiplinger's Personal Finance - July 2012 download from rapidshare & hotfile, megaupload. Kiplinger's Personal Finance - July 2012 magazine pdf subscription (rss). magasine Kiplinger's Personal Finance - July 2012 online

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Trademark Infringement and Likelihood of ... - Traverse Legal, PLC

As a trademark attorney, I see things every day, many of which don?t surprise me anymore.? But I have to say one thing that I really hear a lot in the area of trademark registration and trademark infringement is, ?Hey, my mark is different than the one that is being used by the trademark holder? or ?my mark isn?t exactly the same? or ?my logo is slightly different.? ?What people fail to realize is that trademarks protect around the mark.? They protect more than just the literal use of the word or the design element or the logo or the colors in the related elements of the trademark use.

So if you have trademark rights in a word, logo, symbol, design, slogan, you get to protect more than just the literal use of that trademark.? You get to have the exclusive right to use that mark in commerce as related to your goods and services or any other goods and services that might be similar to yours, and you get to preclude anyone from using something that is similar to the point that there is a likelihood of confusion from the consumer point of view.

So what in the trademark world does this concept of likelihood of confusion mean?? Well, there are any number of different factors that a court would look at in order to determine whether or not someone is infringing a trademark, whether or not there is a likelihood of confusion between the plaintiff?s trademark and the defendant?s use.? The thing that you need to understand is that if you?re in a similar market selling something that is similar, if you?re using a word or design that looks or appears to be similar, consumers might think that the defendant?s trademark or the defendant?s use is in fact sponsored or owned by or endorsed by the plaintiff trademark holder.

So the test of likelihood of confusion is a very broad one, and every case is fact specific.? If you receive a trademark infringement threat letter, someone is alleging that you are infringing their mark in commerce.? Do not rely on the slight differences between what you?re doing and what the complaining party is doing with their mark.? That?s not going to get you anywhere.? You have to put yourself in a consumer?s point of view and say, ?If I saw the two marks side by side and I saw what each company was doing, would I potentially be confused about who was who? Would I be confused about the source and origin of the goods and services that I was buying??? Not only do we protect the Nike Swoosh, in the area of sporting goods and apparel and shoes, but we protect against any use that is similar to the Nike Swoosh, because we don?t want consumers to be confused about who they?re dealing with.

A good trademark infringement attorney is going to tell you, if you receive a cease and desist threat letter for trademark infringement, that you?ve got a big problem if your use is similar.? Here is the problem from the defendant?s point of view.? You might get shut down.?? You?ve got an investment in the use of a domain name perhaps.? Perhaps your using the trademark in your marketing materials.? If you?ve received a trademark infringement threat letter claiming substantial similarity, are you going to continue to invest your time and money in that use, knowing that at some point down the line you could be shut down, and even more so you could be liable in a trademark infringement lawsuit for up to $150,000 and statutory damages plus attorney fees? ?How much time and effort are you going to want to continue to put into that mark?

One thing that trademark lawyers at trademark law firms will do for clients who are in the defensive position who have been accused of trademark infringement is try and negotiate an exit strategy for the defendant when there is a problem.? So if you think that you may be in a difficult situation, either because you can?t afford to fight the fight, or because you now realize that just because your trademark is slightly different that it?s not going to potentially help you in a court of law, or if you didn?t realize that trademark law protects around the trademarks broader than the literal use of the mark but now you do, you need to negotiate an exit.? You might get a joint use agreement with the plaintiff.? You might be able to buy yourself some time to transition out of your current inventory and transition into a new mark.

Here are the lessons for today from this trademark attorney.? Make sure before you brand your goods, your services, your company, you have a competent trademark law firm do a trademark availability search.? You do not want to invest in a brand that you later have to change.? It could put you out of business.? If you?ve already chosen a brand and you receive a trademark infringement threat letter, then you need to get a good trademark law firm involved in order to be able to understand what your risk is, what your rights are, what options you have, and what the recommendation of the attorneys are in terms of moving forward.

My name is trademark attorney Enrico Schaefer, and we?ll see you next time.

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Acne Tips ? 3 Tips to get rid of acne infection ... - Health and Fitness

Are you worried about your acne infection? Are you still worried about your skin? The tone of your skin has begun to interfere too often imperfect? If the answer is yes to a question still is, at the time to read this article carefully.

Keep your face free from oil

Defects are known to attack at will. Especially if you?re a teenager, chances are you may suffer from both blackheads and pimples. To get rid of them, you would have your face with cold water and mild soap. Simply remove the excess oil from your face.

Use a Wrap

Pollution and stress play a role in aggravating an acne infection. To remove contaminants from the surface of the skin just a patch, preferably a fruit of the face, on a weekly basis. You can also try to calm the mind, while soft music.

Apply anti-acne cream

There are a variety of anti-Blemish supplements on the market today. To avoid the appearance of pimples and black, you should try to gloss over a cream on a regular basis. These creams are easily available through an online store. Just order and the cream of your choice should be delivered directly to your home.

To get a good look and perfect complexion, you should try the above tips on a regular basis.

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Plans to strike Iran "ready," says U.S. Israel envoy

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